August 1, 1992Journal of Biological ChemistryOpen Access

Identification of a heparin-releasable lipoprotein lipase binding protein from endothelial cells.

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Population

Endothelial cells

Comparison

Heparin treatment and biochemical characterization vs Control cells (no heparin treatment)

Design

Preclinical

Authors

MKMichal KleinIsrael Institute for Biological Research IGIra J. GoldbergPreventive Cardiology

Discussion

Member takes

Implication

Premature for clinical use in lipid disorders; leaves open hrp-116 validation as LPL target in humans.

Structured PICO

Population

Endothelial cells

Intervention

Heparin treatment (50 units/ml) and biochemical characterization (ligand blotting, affinity chromatography)

Comparator

Control cells (no heparin treatment)

Outcome

Identification and characterization of a 116-kDa lipoprotein lipase (LPL) binding proteinsurrogate

The study identifies hrp-116, a novel heparin-releasable 116-kDa protein on endothelial cells that mediates lipoprotein lipase binding and internalization.

Cite This Study

Klein et al. (1992) studied this question.

synapsesocial.com/papers/6a7dc9fd75afeb5dc533969e https://doi.org/10.1016/s0021-9258(18)42033-9

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Identification of a heparin-releasable lipoprotein lipase binding protein from endothelial cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of a heparin-releasable lipoprotein lipase binding protein from endothelial cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider