Why the study?
Does a low salt diet alter the relationship between renal arterial pressure and plasma renin activity in uninephrectomized conscious dogs?
Does a low salt diet alter the relationship between renal arterial pressure and plasma renin activity in uninephrectomized conscious dogs?
A reduction in salt intake increases the sensitivity of the renal baroreceptor, leading to higher absolute plasma renin activity at any given renal arterial pressure without altering the proportional response to pressure changes.
Low-salt diets reset PRA set-point across pressures in dogs; leaves open translation to human baroreceptor function.
We investigated the relationship between renal arterial pressure (RAP) and systemic plasma renin activity (PRA) in five uninephrectomized conscious dogs on normal salt (80 meq Na+/day) and low salt (10 meq Na+/day) diets. The RAP was controlled by an inflatable cuff placed around the origin of the renal artery. In both salt states the PRA was an exponential function of the RAP: log (PRA) = (-0.026 X RAP) + 2 on the normal salt diet (r = 0.96) and log (PRA) = (-0.026 X RAP) + 2.5 on the low salt diet (r = 0.99). At any RAP, the value of the low salt PRA was 3 times that of the normal salt PRA. Accordingly, a reduction in salt intake increases the sensitivity of the renal baroreceptor so that the absolute value of PRA increases at any RAP, but the percentage change in PRA caused by any change in RAP is the same in both normal and low salt states.
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Farhi et al. (1983) studied this question.
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