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May 1, 1971The Journal of Cell BiologyOpen Access

Transport of Viral Rna in Kb Cells Infected With Adenovirus Type 2

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Population

KB cells infected with the nuclear DNA virus adenovirus type 2

Comparison

Actinomycin 0.04 microg/ml and uridine-H labeling vs Cells untreated with actinomycin

Design

Preclinical

Authors

HRHeschel J. RaskasState University of New YorkCOCase K. OkuboWashington University in St. Louis

Discussion

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Implication

Premature for clinical translation in viral cardiac disease; leaves open ribosome-independent mRNA transport mechanisms in human cells.

Structured PICO

P
Population
KB cells infected with the nuclear DNA virus adenovirus type 2
I
Intervention
Actinomycin 0.04 microg/ml and uridine-(3)H labeling
C
Comparator
Cells untreated with actinomycin
O
Outcome
Messenger RNA transport and viral RNA synthesissurrogate

Demonstrates that viral messenger RNA transport in adenovirus-infected cells can occur independently of ribosome synthesis.

Cite This Study

Raskas et al. (1971) studied this question.

synapsesocial.com/papers/6a761a87b23c009ac9fbdb26https://doi.org/10.1083/jcb.49.2.438
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DEMONSTRATION OF AN UNSTABLE RNA AND OF A PRECURSOR TO RIBOSOMAL RNA IN HELA CELLS1963 · 350 citations
  2. 2The effect of HeLa cell cytoplasm on the rate of sedimentation of RNA.1966 · 64 citations
  3. 3A COMPARISON BETWEEN HETEROGENEOUS NUCLEAR RNA AND POLYSOMAL MESSENGER RNA IN HELA CELLS BY RNA-DNA HYBRIDIZATION1970 · 65 citations
  4. 4Subribosomal particles and the transport of messenger RNA in HeLa cells1965 · 149 citations