Why the study?
The study investigated the impact of cardiovascular risk factors on pregnancy-induced remodeling and postpartum reverse remodeling, aiming to extrapolate findings to pathological conditions.
Do cardiovascular risk factors like arterial hypertension impact postpartum cardiac and vascular reverse remodeling in pregnant women?
Do cardiovascular risk factors like arterial hypertension impact postpartum cardiac and vascular reverse remodeling in pregnant women?
Arterial hypertension during pregnancy impairs postpartum cardiac and vascular reverse remodeling, with ST2/IL33-receptors and CRP identified as potential biomarkers for hypertrophy reversal.
Hypertension may impair postpartum reverse remodeling; hypothesis-generating for ST2/IL-33 and CRP biomarkers pending validation.
This study describes the impact of cardiovascular risk factors (CVR) in pregnancy-induced remodeling and postpartum reverse remodeling (up to 1 yr) by applying advanced statistic methods (multivariate generalized linear mixed-effects models) to a prospective cohort of pregnant women. Aiming to extrapolate to pathological conditions, this invaluable "human model" allowed us to demonstrate that arterial hypertension is a critical CVR for worse RR and that ST2/IL33-receptors and CRP are potential biomarkers of postpartum hypertrophy reversal.
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Ferreira et al. (2023) studied this question.
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