Why the study?
Does disopyramide improve symptoms and reduce mid-ventricular obstruction in a pediatric patient with mid-ventricular hypertrophic obstructive cardiomyopathy?
Does disopyramide improve symptoms and reduce mid-ventricular obstruction in a pediatric patient with mid-ventricular hypertrophic obstructive cardiomyopathy?
Disopyramide effectively reduced mid-ventricular obstruction and improved symptoms in a pediatric patient with mid-ventricular hypertrophic obstructive cardiomyopathy.
Answers are grounded in this paper and cite their sources.
May relieve symptoms in one pediatric mid-ventricular HOCM case; hypothesis-generating and should not change practice.
A 14-year-old boy with mid-ventricular hypertrophic obstructive cardiomyopathy (MVHOCM) first presented at the age of 10 years with severe chest pain. Two-dimensional echocardiography disclosed marked hypertrophy at the mid-portion of the ventricular septum, and left ventriculography showed an hourglass appearance at systole. He was initially treated with propranolol, but the chest pain and dyspnea on exertion worsened at the age of 12 years. After disopyramide was started, the chest pain disappeared and the degree of the pressure gradient at the mid-ventricular level was reduced. There was also significant improvement on a 123I beta-methyliodophenyl pentadecaonic acid (BMIPP) myocardial scintigram.
No takes yet. Share an insight, caveat, or question.
Teraguchi et al. (2002) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: