What question did this study set out to answer?

To assess the efficacy and safety of moderate doses of diazepam for relieving dyspnoea in disabled patients with pink puffer syndrome.

January 1, 1980QJM

Diazepam in the Treatment of Dyspnoea in the ‘Pink Puffer’ Syndrome

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Authors

PMP Mitchell-HeggsSt Thomas' Hospital KMKevin MurphyMemorial Sloan Kettering Cancer Center KMK. MintyCharing Cross Hospital

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Implication

Single-blind placebo-controlled study demonstrates diazepam reduces dyspnoea and improves effort tolerance in pink puffer emphysema, suggesting safe symptomatic relief.

Key Points

To assess the efficacy and safety of moderate doses of diazepam for relieving dyspnoea in disabled patients with pink puffer syndrome.
Conducted a single-blind, placebo-controlled study in N=4 patients severely disabled by chronic airflow obstruction and pink puffer syndrome.
Excluded patients with resting hypercapnia or severe hypoxia, administering moderate doses of diazepam versus placebo.
Evaluated dyspnoea severity, effort tolerance, ventilatory response to CO2, resting blood gas levels, and post-treatment psychiatric status.
Diazepam produced a striking reduction in dyspnoea and improved effort tolerance compared to placebo.
Treatment reduced the slope of the ventilation/CO2 response curve without inducing any changes in resting blood gases.

Cite This Study

Mitchell-Heggs et al. (1980) studied this question.

synapsesocial.com/papers/6a761f5d9c92392688b277be https://doi.org/10.1093/oxfordjournals.qjmed.a067609

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Implication

Single-blind placebo-controlled study demonstrates diazepam reduces dyspnoea and improves effort tolerance in pink puffer emphysema, suggesting safe symptomatic relief.

Diazepam in the Treatment of Dyspnoea in the ‘Pink Puffer’ Syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

Diazepam in the Treatment of Dyspnoea in the ‘Pink Puffer’ Syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

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