Systemic and Coronary Hemodynamic Effects of Diazepam in Patients with Normal and Diseased Coronary Arteries
Key result
IV diazepam linked to lower LVEDP and aortic pressure regardless of CAD status.
- P<0.01
- n=20
Why the study?
The systemic and coronary hemodynamic effects of diazepam in patients with normal and diseased coronary arteries were not well characterized.
Does intravenous diazepam affect systemic and coronary hemodynamics in patients undergoing coronary angiography?
Population
20 patients undergoing coronary angiography including 12 with significant coronary artery disease and 8 with normal coronary arteries
Comparison
Hemodynamic measurements before versus after intravenous diazepam administration
Design
Observational study
Follow-up
20 minutes
Authors
Discussion
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Implication
May lower preload and afterload during angiography; leaves open whether routine use reduces myocardial oxygen demand.
Study Design
Type
Observational (n=20)
Structured PICO
Does intravenous diazepam affect systemic and coronary hemodynamics in patients undergoing coronary angiography?
P
Population
20 patients with significant coronary artery disease or normal coronary arteries undergoing coronary angiography, assessed for hemodynamic effects of diazepam.
I
Intervention
Diazepam 5 to 8.5 mg intravenously before coronary angiography.
C
Comparator
Baseline measurements before diazepam administration.
O
Outcome
Systemic and coronary hemodynamics (heart rate, aortic pressure, cardiac index, left ventricular end-diastolic pressure, tension-time index, myocardial oxygen consumption) at 10 and 20 minutes after diazepam.surrogate
Main Result
p-value: p=<0.01
Intravenous diazepam provides a nitroglycerin-like reduction in preload and afterload, decreasing myocardial oxygen demand during coronary angiography.
Cite This Study
Côté et al. (1974) conducted an observational in Coronary artery disease or normal coronary arteries (n=20). Diazepam vs. Baseline was evaluated on Left ventricular end-diastolic pressure (LVEDP) (p=<0.01). Intravenous diazepam significantly decreased left ventricular end-diastolic pressure (P<0.01) and aortic pressure in patients with and without coronary artery disease.