Why the study?
Does diazepam induce coronary vasodilation and alter myocardial contractility in anaesthetized dogs?
Population
Anaesthetized dogs on cardiopulmonary bypass under conditions of constant heart rate and aortic pressure
Comparison
Diazepam vs Systemic administration of diazepam
Design
Preclinical
Follow-up
30 minutes (duration of effect)
Authors
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Should not change clinical practice; hypothesis-generating for diazepam coronary effects with human translation needed.
Does diazepam induce coronary vasodilation and alter myocardial contractility in anaesthetized dogs?
In a canine model, diazepam produces coronary vasodilation and augments myocardial contractility secondary to increased coronary blood flow.
Abel et al. (1970) studied this question.
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