Key result
Diazepam (100 microM) significantly decreased maximum contracture during ischemia and improved the recovery of myocardial function and coronary flow in reperfusion in isolated rat hearts.
Why the study?
Does diazepam improve functional recovery in isolated rat hearts subjected to ischemia-reperfusion?
Population
Isolated, perfused rat hearts subjected to 40 minutes normothermic global ischemia and 45 minutes reperfusion
Comparison
Diazepam added to the perfusion solution for 10… vs Control group (no diazepam)
Design
Preclinical
Follow-up
85 minutes (40 minutes ischemia and 45 minutes reperfusion)
Authors
Loading...
Diazepam cardioprotection in rat hearts is hypothesis-generating; leaves open translation to human ischemia-reperfusion injury.
Does diazepam improve functional recovery in isolated rat hearts subjected to ischemia-reperfusion?
Diazepam at cardio depressant concentrations provides protective effects in isolated rat hearts during ischemia-reperfusion, potentially by inhibiting calcium currents.
Shackebaei et al. (2008) studied Ischemia-reperfusion (n=24). Diazepam vs. Control group was evaluated on Maximum contracture during ischemia, functional recovery, and coronary flow in reperfusion. Diazepam (100 microM) significantly decreased maximum contracture during ischemia and improved the recovery of myocardial function and coronary flow in reperfusion in isolated rat hearts.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: