June 6, 2008Pharmacology

Ro 5-4864 and PK 11195, but Not Diazepam, Depress Cardiac Function in an Isolated Working Rat Heart Model

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Population

Isolated working rat heart model

Design

Preclinical

Authors

YEY EdouteMedical Technologies (Czechia)JGJacob GirisTel Aviv University SBShlomo A. Ben‐HaimElectrophysiology

Discussion

Member takes

Implication

Peripheral benzodiazepine ligands may impair contractility at high concentrations in isolated hearts; leaves open clinical relevance in humans.

Structured PICO

Population

Isolated working rat heart model

Intervention

Diazepam, Ro 5-4864, and PK 11195 at five concentrations (10(-9)-10(-5) mol/l)

Outcome

Chronotropic (heart rate) and inotropic parameters (maximum elastance of the left ventricle at end systole [Emax], maximal first derivative of left ventricular pressure [dP/dtmax], LV pressure at dP/dtmax, aortic flow, stroke work, and total pressure-volume area)surrogate

Specific mitochondrial benzodiazepine receptor ligands (Ro 5-4864 and PK 11195) depress cardiac mechanical function at high concentrations in isolated rat hearts, unlike the central ligand diazepam.

Cite This Study

Edoute et al. (2008) studied this question.

synapsesocial.com/papers/6a8223cd820a57e9dc877911 https://doi.org/10.1159/000139049

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Implication

Peripheral benzodiazepine ligands may impair contractility at high concentrations in isolated hearts; leaves open clinical relevance in humans.

Ro 5-4864 and PK 11195, but Not Diazepam, Depress Cardiac Function in an Isolated Working Rat Heart Model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ro 5-4864 and PK 11195, but Not Diazepam, Depress Cardiac Function in an Isolated Working Rat Heart Model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider