What question did this study set out to answer?

To evaluate the hemodynamic and ventilatory consequences of administering intravenous diazepam to alleviate acute anxiety during cardiac catheterization.

March 1, 1969AnesthesiologyOpen Access

The Hemodynamic and Respiratory Effects of Diazepam (Valium®)

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Why the study?

Does intravenous diazepam affect hemodynamic and respiratory parameters in patients experiencing anxiety during cardiac catheterization?

Population

15 patients experiencing anxiety during cardiac catheterization

Comparison

Diazepam 5-10 mg intravenously vs Baseline (before diazepam administration)

Design

Case_series

Follow-up

30 minutes

Authors

JDJames E. DalenGeneral Cardiology GEGerald L. EvansMcMaster University Medical Centre JBJohn S. BanasTufts University

Discussion

Member takes

Implication

Diazepam may be considered for procedural anxiety in catheterization; case-report data leave open confirmation in controlled trials.

Key Points

To evaluate the hemodynamic and ventilatory consequences of administering intravenous diazepam to alleviate acute anxiety during cardiac catheterization.
Administered 5–10 mg of intravenous diazepam to treat acute anxiety in 15 patients undergoing cardiac catheterization.
Measured hemodynamic and respiratory parameters prior to drug injection as well as 10 and 30 minutes post-administration.
Anxiety was relieved in 11 of 15 patients, and systolic blood pressure fell by over 10 mm Hg in eight patients without significant changes in heart rate, stroke volume, or vascular resistance.
Cardiac index decreased significantly in only three patients who began with high-normal control values, exhibiting no significant alterations in patients with below-normal baseline levels.
Hypoventilation developed in all patients, marked at 10 minutes by a 28% decrease in minute ventilation, a 23% reduction in tidal volume, a 5 mm Hg increase in Paco2, and a 10 mm Hg decrease in Pao2, none requiring clinical intervention.

Structured PICO

Does intravenous diazepam affect hemodynamic and respiratory parameters in patients experiencing anxiety during cardiac catheterization?

Population

15 patients experiencing anxiety during cardiac catheterization

Intervention

Diazepam 5-10 mg intravenously

Comparator

Baseline (before diazepam administration)

Outcome

Hemodynamic and ventilatory parameters at 10 and 30 minutes after diazepamsurrogate

Intravenous diazepam effectively relieves anxiety during cardiac catheterization and, while causing measurable hypoventilation and mild blood pressure decreases, does not produce clinically significant adverse hemodynamic or respiratory effects requiring intervention.

Cite This Study

Dalen et al. (1969) studied this question.

synapsesocial.com/papers/6a75d807f56d87d9178b6bfe https://doi.org/10.1097/00000542-196903000-00002

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The Hemodynamic and Respiratory Effects of Diazepam (Valium®)

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The Hemodynamic and Respiratory Effects of Diazepam (Valium®)

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider