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September 1, 1975Anesthesia & Analgesia

Relation of Anesthesia to Total Hip Replacement and Control of Operative Blood Loss

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Why the study?

Does moderate lowering of intraoperative systolic blood pressure reduce operative blood loss in patients undergoing total hip replacement?

Population

225 patients undergoing total hip replacement (167 in retrospective case reports, 58 in prospective study)

Comparison

Moderate lowering of intraoperative systolic… vs Standard intraoperative systolic blood pressure

Design

Cohort

Follow-up

intraoperative

Authors

LAL. AmaranathCleveland ClinicHCH. F. CascorbiUniversity Hospitals of ClevelandASA. V. SINGH-AMARANATHCase Western Reserve University

Discussion

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Implication

May reduce blood loss in hip replacement; hypothesis-generating and requires randomized confirmation before practice change.

Structured PICO

Does moderate lowering of intraoperative systolic blood pressure reduce operative blood loss in patients undergoing total hip replacement?

P
Population
225 patients undergoing total hip replacement (167 in retrospective case reports, 58 in prospective study)
I
Intervention
Moderate lowering of intraoperative systolic blood pressure by 20 to 30 percent of preoperative value using trimethaphan or sodium nitroprusside
C
Comparator
Standard intraoperative systolic blood pressure
O
Outcome
Operative blood losssurrogate

Moderate lowering of intraoperative systolic blood pressure during total hip replacement significantly reduces operative blood loss and transfusion requirements.

Cite This Study

Amaranath et al. (1975) studied this question.

synapsesocial.com/papers/6a76201fcd662f67b2fbdb58https://doi.org/10.1213/00000539-197509000-00020
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anesthetic Techniques and Surgical Blood Loss in Total Hip Arthroplasty1982 · 58 citations
  2. 2The use of spinal anesthesia for total hip-replacement arthroplasty1975 · 80 citations
  3. 3Moderate Hypotensive Anaesthesia for Reduction of Blood Loss During Total Hip Replacement1982 · 21 citations
  4. 4The Effect of Two Levels of Hypotension on Intraoperative Blood Loss During Total Hip Arthroplasty Performed Under Lumbar Epidural Anesthesia1993 · 35 citations
  5. 5Postoperative Pain Significantly Influences Postoperative Blood Loss in Patients Undergoing Total Knee Replacement2006 · 40 citations