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November 1, 2006Pain Medicine

Postoperative Pain Significantly Influences Postoperative Blood Loss in Patients Undergoing Total Knee Replacement

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Why the study?

Does postoperative pain influence postoperative blood loss in patients undergoing primary total knee replacement?

Population

60 patients undergoing primary total knee replacement (TKR)

Comparison

Intravenous patient-controlled analgesia plus… vs Intravenous patient-controlled analgesia alone

Design

RCT, randomized

Follow-up

96 hours

Authors

JGJoanne GuayUniversité du Québec en Abitibi-Témiscamingue

Discussion

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Implication

High morphine needs may flag greater blood-loss risk after TKA; leaves open whether analgesia optimization reduces bleeding.

Structured PICO

Does postoperative pain influence postoperative blood loss in patients undergoing primary total knee replacement?

P
Population
60 patients undergoing primary total knee replacement (TKR)
I
Intervention
Intravenous patient-controlled analgesia (PCA) plus continuous femoral nerve (three-in-one) block or PCA plus continuous posterior lumbar plexus (psoas compartment) block
C
Comparator
Intravenous patient-controlled analgesia (PCA) alone
O
Outcome
Perioperative blood losses (measured and calculated), number of transfused units, and late (96 hours) postoperative hemoglobinsurrogate

Postoperative pain, as indicated by morphine consumption, is significantly correlated with increased postoperative blood loss in patients undergoing total knee replacement.

Cite This Study

Joanne Guay (2006) studied this question.

synapsesocial.com/papers/6a8933221e528df4f2ec6095https://doi.org/10.1111/j.1526-4637.2006.00236.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Controlled Hypotensive Anesthesia During Spinal Surgery1984 · 43 citations
  2. 2Hypotensive epidural anesthesia for total hip arthroplasty: A review1996 · 164 citations
  3. 3The Predictive Power of Baseline Hemoglobin for Transfusion Risk in Surgery Patients1999 · 99 citations
  4. 4The use of a closed-suction drain in total knee arthroplasty2003 · 177 citations
  5. 5A Comparative Study of the Postoperative Allogeneic Blood-Sparing Effect of Tranexamic Acid Versus Acute Normovolemic Hemodilution After Total Knee Replacement1999 · 55 citations