Why the study?
Urinary tract infection is common in children and urinary angiotensinogen is a biomarker reflecting intrarenal renin-angiotensin system activity, motivating measurement of urinary angiotensinogen in young infants with UTI.
Are urinary angiotensinogen levels elevated in children <4 months old with urinary tract infection compared to those without?
Are urinary angiotensinogen levels elevated in children <4 months old with urinary tract infection compared to those without?
Urinary angiotensinogen is elevated in infants with UTI, suggesting intrarenal renin-angiotensin system activation may contribute to UTI-induced renal injury.
BACKGROUND: Urinary tract infection (UTI) is one of the most common diseases in children, and urinary angiotensinogen (U-AGT) is a new biomarker gathering attention in many renal diseases. U-AGT reflects intrarenal renin-angiotensin system (RAS) activity. We conducted a study to measure U-AGT in children <4 months old with UTI. METHODS: All children <4 months old who came to Toshima Hospital with fever between January 2015 and December 2015 were included. Patients were divided into a UTI group and a non-UTI group, and U-AGT was measured. RESULTS: Median U-AGT was higher in patients with UTI compared with patients without UTI: (0.56 ng/dL, range, 0.025-2.753 ng/dL vs 0.13 ng/dL, range, 0.008-1.697 ng/dL, respectively; P < 0.05). CONCLUSIONS: U-AGT is elevated in UTI patients, and RAS activation may contribute to renal injury caused by UTI.
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Mayumi et al. (2019) studied this question.
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