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December 15, 2008HypertensionOpen Access

Urinary Angiotensinogen as a Novel Biomarker of the Intrarenal Renin-Angiotensin System Status in Hypertensive Patients

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Why the study?

Is urinary angiotensinogen increased in hypertensive patients and modulated by RAS blockers?

Population

106 adults. Excluded: estimated glomerular filtration levels <30 mL/min per 1.73 m.

Comparison

Hypertension vs Normotensive subjects

Design

Cross-sectional

Authors

HKHiroyuki KoboriGeneral / Preventive / LipidsAAArnold AlperTulane UniversityRSRajesh ShenavaTulane University

Discussion

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Overview

May support UAGT as intrarenal RAS biomarker in hypertension; hypothesis-generating and should not yet change practice.

Structured PICO

Is urinary angiotensinogen increased in hypertensive patients and modulated by RAS blockers?

P
Population
106 adults (70 hypertensive patients and 36 normotensive subjects). Excluded: estimated glomerular filtration levels <30 mL/min per 1.73 m(2).
I
Intervention
Hypertension (with or without RAS blockers [ACE inhibitors or ARBs])
C
Comparator
Normotensive subjects
O
Outcome
Urinary angiotensinogen (UAGT) normalized by urinary concentrations of creatininesurrogate

Urinary angiotensinogen is elevated in hypertensive patients and suppressed by RAS blockers, suggesting its utility as a biomarker for assessing intrarenal RAS activity.

Cite This Study

Kobori et al. (2008) studied this question.

synapsesocial.com/papers/6a76cfd6d2fa2470761e7409https://doi.org/10.1161/hypertensionaha.108.123802
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