Urinary Angiotensinogen as an Indicator of Intrarenal Angiotensin Status in Hypertension

Rats divided into 4 groups: normal salt diet with sham operation (n=6); normal salt with AngII infusion at 40 ng/min (n=9); normal salt with AngII infusion at 80 ng/min (n=9); high-salt diet with deoxycorticosterone acetate salt pellet (100 mg) (n=4). Additional rats for human angiotensinogen infusion experiment (n=4 sham, n=4 AngII-infused).

Angiotensin II infusion (40 or 80 ng/min via osmotic minipump) or high-salt diet with deoxycorticosterone acetate (DOCA) salt pellet (100 mg)

Normal salt diet with sham operation

Urinary angiotensinogen excretion (U(AGT)) and intrarenal AngII contentsurrogate