Why the study?
Does an orthostatic challenge reveal noradrenergic dysregulation in patients with depressive disorders compared to healthy volunteers?
Population
53 subjects, including bipolar depressives, unipolar depressives, and partially age-matched healthy female…
Comparison
Orthostatic challenge (five minutes of standing) vs Rest (supine position)
Design
Case-control
Authors
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May support noradrenergic dysregulation in depression; hypothesis-generating and should not yet change practice.
Does an orthostatic challenge reveal noradrenergic dysregulation in patients with depressive disorders compared to healthy volunteers?
Depression is characterized by an exaggerated, inefficient hyperreactivity of plasma norepinephrine to physiologic orthostatic stress.
Matthew V. Rudorfer (1985) studied this question.
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