Why the study?
Is the change in plasma norepinephrine during head-up tilt a reliable diagnostic test for autonomic failure?
Population
6 patients with pure autonomic failure and 8 healthy subjects
Comparison
30 degrees head-up tilting vs Recumbency (baseline) and healthy subjects
Design
Case-control
Authors
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Plasma NE rise on tilt warrants cautious interpretation in autonomic failure; leaves open diagnostic test reliability.
Is the change in plasma norepinephrine during head-up tilt a reliable diagnostic test for autonomic failure?
Measuring plasma norepinephrine changes during postural stimulation is not a reliable diagnostic test for autonomic failure because levels can rise due to reduced clearance rather than increased sympathetic activity.
Meredith et al. (1992) studied this question.
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