Why the study?
Does ouabain affect atrioventricular junctional automaticity and conductivity in anesthetized dogs?
Does ouabain affect atrioventricular junctional automaticity and conductivity in anesthetized dogs?
Ouabain has differential dose-dependent effects on automaticity in the A-V junction versus ventricular specialized fibers in dogs.
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Caution against extrapolating canine findings to patients; leaves open human relevance of dose-dependent effects.
In the anesthetized dog, the effects of ouabain injected intravenously and directly into the atrioventricular (A-V) node artery were studied. Automaticity within the A-V junction was decreased after a dose of ouabain, 30 μg/kg given intravenously (i.v.), whereas automaticity of ventricular specialized fibers was increased after a dose of 40 μg/kg i.v. The decrease of automaticity within the A-V junction was accompanied by an increased duration of the functional refractory period of this structure and by a prolongation of conduction time through the A-V junction as determined from the His bundle electrogram.
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Elharrar et al. (1974) studied this question.
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