January 1, 2010Korean Journal of Physiology and PharmacologyOpen Access

Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice

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Why the study?

Does metformin prevent isoproterenol-induced cardiac hypertrophy in mice?

Population

Male C57BL/6J mice weighing 20 g

Comparison

Metformin coinfused with isoproterenol via… vs Saline infusion, isoproterenol alone, or…

Design

Preclinical

Follow-up

1 week

Authors

HCHye-Na ChaYeungnam University JCJung Hyun ChoiCardiac Imaging YKYong‐Woon KimJeju National University

Discussion

Member takes

Implication

Should not change clinical practice; leaves open whether metformin's effects translate beyond this animal model.

Structured PICO

Does metformin prevent isoproterenol-induced cardiac hypertrophy in mice?

Population

Male C57BL/6J mice weighing 20 g

Intervention

Metformin (150 mg/kg/24 h) coinfused with isoproterenol (15 mg/kg/24 h) via subcutaneous osmotic minipump for 1 week

Comparator

Saline infusion (control), isoproterenol alone (15 mg/kg/24 h), or metformin alone (150 mg/kg/24 h)

Outcome

Cardiac hypertrophy measured by heart-to-body weight ratio and left ventricular posterior wall thicknesssurrogate

Metformin partially inhibits isoproterenol-induced cardiac hypertrophy in mice, likely through attenuation of oxidative stress rather than chronic AMPK activation in the heart.

Cite This Study

Cha et al. (2010) studied this question.

synapsesocial.com/papers/6a7623141ee3153e8f613e30 https://doi.org/10.4196/kjpp.2010.14.6.377

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Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider