Why the study?
Metformin improves cardiovascular outcomes in type-2 diabetes independently of insulin sensitization, but its cardioprotective effects against isoproterenol-induced cardiac stress in diabetic and non-diabetic models required evaluation.
Does metformin prevent isoproterenol-induced cardiotoxicity in diabetic and non-diabetic male rats?
Population
Diabetic and non-diabetic male rats
Comparison
Different doses of metformin (75, 150, 300 mg/kg i.p.) vs controls during isoproterenol-induced cardiac stress
Design
Randomized preclinical animal study
Authors
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Metformin attenuated cardiac stress in diabetic rats; leaves open translation to human cardiovascular prevention.
Does metformin prevent isoproterenol-induced cardiotoxicity in diabetic and non-diabetic male rats?
Metformin demonstrates cardioprotective effects against isoproterenol-induced cardiac stress in both diabetic and non-diabetic rat models by reducing injury biomarkers.
Al-Qaisy et al. (2021) studied this question.
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