Why the study?
Does metformin improve myocardial tolerance to ischemia-reperfusion injury in a rat model of type 2 diabetes mellitus?
Population
Rats with neonatal streptozotocin-induced type 2 diabetes mellitus subjected to a model of global…
Comparison
Metformin administered intraperitoneally at a… vs Controls (untreated animals)
Design
Preclinical
Authors
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No direct cardioprotection from short-term metformin in diabetic rat IRI; leaves open alternative mechanisms for clinical cardiovascular benefits.
Does metformin improve myocardial tolerance to ischemia-reperfusion injury in a rat model of type 2 diabetes mellitus?
Short-term metformin administration did not elicit a direct cardioprotective effect against ischemia-reperfusion injury in a rat model of T2DM, suggesting its clinical cardiovascular benefits may rely on different mechanisms.
Кравчук et al. (2011) studied this question.
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