May 1, 2009Journal of Cardiovascular Pharmacology

Metformin Prevents Myocardial Reperfusion Injury by Activating the Adenosine Receptor

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Why the study?

Does metformin given at reperfusion reduce myocardial infarct size in a rat model of myocardial infarction?

Population

Sprague-Dawley rats

Comparison

Metformin vs Control and metformin combined with adenosine…

Design

Preclinical

Follow-up

120 minutes of reperfusion

Authors

MPMarta PaivaInstituto de Biologia Experimental e Tecnológica NRNiels P. RiksenRadboud University Nijmegen SDSean M. DavidsonCardiovascular Institute of the South

Discussion

Member takes

Implication

Metformin at reperfusion merits testing in clinical MI trials; hypothesis-generating in animals and leaves open human translation.

Structured PICO

Does metformin given at reperfusion reduce myocardial infarct size in a rat model of myocardial infarction?

Population

Sprague-Dawley rats (isolated perfused hearts subjected to 35 minutes of regional ischemia and 120 minutes of reperfusion, and an in situ model of myocardial infarction)

Intervention

Metformin (50 microM perfusion for the first 15 minutes of reperfusion in isolated hearts; 5 mg/kg intravenous administration in the in situ model)

Comparator

Control (no metformin) and metformin combined with adenosine receptor antagonist (8-p-sulfophenyltheophylline) or adenosine transport blocker (nitrobenzylthioinosine)

Outcome

Myocardial infarct size (percent area at risk)surrogate

Metformin administered at the time of reperfusion significantly reduces myocardial infarct size in rats via an adenosine receptor-dependent mechanism.

Cite This Study

Paiva et al. (2009) studied this question.

synapsesocial.com/papers/6a8a572d1e528df4f2ec717a https://doi.org/10.1097/fjc.0b013e31819fd4e7

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Metformin Prevents Myocardial Reperfusion Injury by Activating the Adenosine Receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Metformin Prevents Myocardial Reperfusion Injury by Activating the Adenosine Receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider