Key result
Metformin significantly preserved ATP levels during myocardial ischemia compared to control (65% vs 42% of baseline, p<0.01), a cardioprotective effect abolished by nitric oxide synthase inhibition.
Why the study?
Does metformin improve myocardial energy metabolism during ischemia in isolated rabbit hearts?
Population
28 isolated rabbit hearts subjected to 45 min of normothermic global ischemia
Comparison
Metformin administered 60 min prior to induction… vs Control group receiving no metformin or L-NAME
Design
Preclinical
Follow-up
45 minutes (duration of ischemia)
Authors
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Metformin may confer NO-dependent cardioprotection during ischemia in isolated hearts; leaves open translation to clinical use.
Does metformin improve myocardial energy metabolism during ischemia in isolated rabbit hearts?
Absolute Event Rate: 65% vs 42%
p-value: p=<0.01
Metformin preserves myocardial ATP levels during ischemia in a nitric oxide synthase-dependent manner in isolated rabbit hearts.
Kawabata et al. (2003) studied Myocardial ischemia (n=28). Metformin vs. Vehicle (physiologic saline) was evaluated on Adenosine triphosphate (ATP) level at 42.5 minutes of ischemia (percentage of initial value) (p=<0.01). Metformin significantly preserved ATP levels during myocardial ischemia compared to control (65% vs 42% of baseline, p<0.01), a cardioprotective effect abolished by nitric oxide synthase inhibition.
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