Why the study?
Does metformin improve cardiac functional recovery after ischemia in an isolated rat heart model?
Population
Isolated, erythrocyte perfused, rat working-heart model (total n=6)
Comparison
Metformin 50 and 500 micromol/l vs Vehicle
Design
Preclinical
Authors
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Hypothesis-generating for metformin's direct cardioprotection; human studies required before clinical consideration.
Does metformin improve cardiac functional recovery after ischemia in an isolated rat heart model?
Metformin acutely improves cardiac functional recovery and reduces functional loss after mild ischemia in an isolated rat heart model, suggesting direct beneficial effects on the heart.
Legtenberg et al. (2002) studied this question.
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