February 1, 1994AJP Heart and Circulatory Physiology
Metformin improves cardiac function in isolated streptozotocin-diabetic rat hearts
Why the study?
Does metformin improve cardiac function in streptozotocin-diabetic rats?
Population
Control and streptozotocin-treated diabetic rats
Comparison
Metformin hydrochloride for 8 weeks vs Untreated diabetic rats and age-matched…
Design
Preclinical
Follow-up
8 weeks
Authors
Discussion
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Implication
Does not support clinical use in diabetic cardiomyopathy; leaves open translation from rodent models.
Key Points
- To evaluate whether chronic metformin treatment improves cardiac performance and hemodynamic responses to preload stress in isolated hearts from streptozotocin-induced diabetic rats.
- Administered metformin hydrochloride orally to control and streptozotocin-induced diabetic rats for 8 weeks, escalating from 350 mg/kg/day to a maintenance dose of 650 mg/kg/day for 6 weeks.
- Assessed isolated perfused working heart hemodynamics across left atrial filling pressures ranging from 15 to 22.5 cmH2O at a controlled heart rate of 300 beats/min.
- Untreated diabetic hearts exhibited depressed left ventricular developed pressure, contractility, and relaxation at filling pressures of 17.5 to 22.5 cmH2O, all of which metformin restored to control levels.
- Metformin treatment significantly decreased plasma glucose from 24.3 mM to 14.4 mM without altering insulin levels, while normalizing elevated plasma triglycerides to control levels in diabetic rats.
Structured PICO
Does metformin improve cardiac function in streptozotocin-diabetic rats?
P
Population
Control and streptozotocin-treated diabetic rats
I
Intervention
Metformin hydrochloride (initiated at 350 mg/kg/day, gradually increased to 650 mg/kg/day) for 8 weeks
C
Comparator
Untreated diabetic rats and age-matched untreated control rats
O
Outcome
Cardiac performance under conditions of increasing preload (left ventricular developed pressure, ventricular contractility, and ventricular relaxation)surrogate
Metformin administration improves cardiac performance and metabolic parameters in a rat model of streptozotocin-induced diabetes.
Cite This Study
Verma et al. (1994) studied this question.