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May 14, 2011AJP Heart and Circulatory Physiology

Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure

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Why the study?

Does metformin improve cardiac function and remodeling in a nondiabetic rat model of post-MI heart failure?

Population

Male, nondiabetic, Sprague-Dawley rats subjected to either myocardial infarction (MI) or sham operation.

Comparison

Metformin-containing water (250 mg·kg·day) for… vs Normal water (MI control).

Design

Preclinical, Randomly allocated

Follow-up

12 weeks

Authors

MYMeimei YinWuXi AppTec (China)IHIwan C.C. van der HorstGeneral CardiologyJMJoost P. van MelleAdult Congenital Heart Disease

Discussion

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Overview

May attenuate post-MI remodeling in nondiabetic models; leaves open translation to human HF therapy.

Structured PICO

Does metformin improve cardiac function and remodeling in a nondiabetic rat model of post-MI heart failure?

P
Population
Male, nondiabetic, Sprague-Dawley rats subjected to either myocardial infarction (MI) or sham operation.
I
Intervention
Metformin-containing water (250 mg·kg(-1)·day(-1)) for 12 weeks.
C
Comparator
Normal water (MI control).
O
Outcome
Cardiac function and remodeling (infarct size, left ventricular dilatation, and left ventricular ejection fraction) assessed 12 weeks after MI.surrogate

Metformin attenuates adverse cardiac remodeling and preserves left ventricular function after myocardial infarction in a nondiabetic rat model.

Cite This Study

Yin et al. (2011) studied this question.

synapsesocial.com/papers/6a8a572d1e528df4f2ec7179https://doi.org/10.1152/ajpheart.00054.2011
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