Why the study?
Does spironolactone prevent cardiac hypertrophy and fibrosis in Wistar rats fed a high salt diet?
Population
Wistar rats
Comparison
Spironolactone added to a high salt diet for 4… vs Regular salt diet or high salt diet without…
Design
Preclinical
Follow-up
8 weeks
Authors
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Spironolactone's benefits remain confined to rat models; leaves open whether mineralocorticoid blockade prevents salt-induced cardiac remodeling in patients.
Does spironolactone prevent cardiac hypertrophy and fibrosis in Wistar rats fed a high salt diet?
Spironolactone prevents cardiac hypertrophy and fibrosis induced by a chronic high salt diet in a rat model, suggesting a role for cardiac aldosterone in mediating these effects.
Ashwin K. Lal (2003) studied this question.
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