July 1, 1989The Journal of General PhysiologyOpen Access

Interactions of protons with single open L-type calcium channels. Location of protonation site and dependence of proton-induced current fluctuations on concentration and species of permeant ion.

View Full Paper

Ask AI

Bookmark

Population

Single open L-type calcium channels

Design

Preclinical

Authors

BPBlaise Prod'homBoston University DPDaniela PietrobonUniversity of Padua PHPhilip E. HessUniversity of Florida

Discussion

Member takes

Implication

Extracellular L-type Ca channel protonation lacks physiological effect; leaves open relevance to human cardiac conduction.

Structured PICO

Population

Single open L-type calcium channels

Intervention

Protons (varying pH) and different concentrations/species of permeant ions (K, Li, Ba, Na)

Outcome

Proton-induced current fluctuations and conductance levelssurrogate

This basic science study demonstrates that proton interaction with L-type calcium channels occurs at an extracellular site and indirectly affects conduction, though these fluctuations do not occur at physiological calcium concentrations.

Cite This Study

Prod'hom et al. (1989) studied this question.

synapsesocial.com/papers/6a762a8eb515f78917fbe097 https://doi.org/10.1085/jgp.94.1.23

View Full Paper

Ask AI

Bookmark

Interactions of protons with single open L-type calcium channels. Location of protonation site and dependence of proton-induced current fluctuations on concentration and species of permeant ion.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Interactions of protons with single open L-type calcium channels. Location of protonation site and dependence of proton-induced current fluctuations on concentration and species of permeant ion.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider