Population
Guinea pig ventricular myocytes (cell-attached patches)
Comparison
Extracellular protons (varying pH levels) vs Different pH levels (e.g., pH 7.4)
Design
Preclinical
Authors
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Low pHo may shift cardiac Na channel availability in acidosis; leaves open human relevance and arrhythmia mechanisms.
Extracellular protons reduce single cardiac sodium channel current amplitude and shift gating parameters, likely due to titration of negative external surface charge.
Zhang et al. (1991) studied this question.
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