Key result
The calcium current of isolated guinea pig ventricular cells is much more sensitive to intracellular protons than extracellular ones.
Population
Isolated guinea pig ventricular cells
Comparison
External or internal application of protons vs Varying internal buffer strengths and blockade…
Design
Preclinical
Authors
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May suppress ICa during acidosis with weak intracellular buffering; leaves open relevance to ischemic Ca handling.
The calcium current in ventricular cells is significantly more sensitive to intracellular protons than extracellular protons.
Irisawa et al. (1986) studied this question. External or internal application of protons (acidification) vs. Baseline or different pH levels was evaluated on Calcium current. The calcium current of isolated guinea pig ventricular cells is much more sensitive to intracellular protons than extracellular ones.
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