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September 1, 1988The Journal of PhysiologyOpen Access

Inhibition of the calcium channel by intracellular protons in single ventricular myocytes of the guinea‐pig.

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Population

Single ventricular myocytes of guinea-pigs

Design

Preclinical

Authors

MKMuneshige KaibaraNagasaki UniversityMKMasaki KameyamaShinshu University

Discussion

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Overview

May inhibit L-type Ca2+ currents during acidosis in myocytes; leaves open human relevance.

Structured PICO

P
Population
Single ventricular myocytes of guinea-pigs
I
Intervention
Intracellular protons (Hi+)
O
Outcome
L-type Ca2+ channel activity (unitary Ba2+ current, open-state probability, gating mechanisms)surrogate

Intracellular protons inhibit L-type calcium channels in guinea-pig ventricular myocytes primarily by altering slow gating mechanisms.

Cite This Study

Kaibara et al. (1988) studied this question.

synapsesocial.com/papers/6a7556ef8d2049c8dd036e0fhttps://doi.org/10.1113/jphysiol.1988.sp017268
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of intracellular acidification on membrane currents in ventricular cells of the guinea pig.1985 · 88 citations
  2. 2Sodium and calcium channels in bovine chromaffin cells1982 · 969 citations
  3. 3Dihydropyridine derivatives prolong the open state of Ca channels in cultured cardiac cells.1984 · 322 citations
  4. 4Properties of adenosine‐triphosphate‐regulated potassium channels in guinea‐pig ventricular cells.1985 · 342 citations
  5. 5The effect of extracellular low pH on the plateau current in isolated, single rat ventricular cells - A voltage clamp study.1983 · 23 citations