Why the study?
Does weight loss induced by a low-fat diet limit the progression of established angiotensin II-induced abdominal aortic aneurysms in obese mice?
Population
Male C57BL/6 mice fed a high-fat diet for 4 months and infused with angiotensin II for 3 months, with…
Comparison
Low-fat diet to induce weight loss for the last… vs Continued high-fat diet for the last 2 months of…
Design
Preclinical
Follow-up
2 months
Authors
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Weight loss may attenuate established AAA progression in obese models; hypothesis-generating and requires human validation before clinical consideration.
Does weight loss induced by a low-fat diet limit the progression of established angiotensin II-induced abdominal aortic aneurysms in obese mice?
Weight loss limits adventitial expansion and neovascularization of established angiotensin II-induced abdominal aortic aneurysms in an obese mouse model.
Police et al. (2010) studied this question.
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