Human lymphoblastoid cells can be infected with Rauscher leukemia virus via in vivo diffusion chamber cultivation, producing nonleukemogenic particles that offer protection against RLV challenge.
Should not change leukemia management; leaves open viral interference as hypothesis-generating in cell models.
Diffusion chambers containing EBV-bearing human lymphoblastoid cells were placed temporarily within the peritoneal cavity of BALB/c mice with Rauscher leukemia. Reestablished human leukocyte cultures became dually infected with C type and EBV particles and have continuously produced abundant C type particles. These virus particles were nonleukemogenic when inoculated into BALB/c mice but afforded some protection against challenge infection with spleen-derived leukemogenic RLV.
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Miyoshi et al. (1973) studied this question.
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