Why the study?
Does altering potassium concentration affect the action of lidocaine and diphenylhydantoin on the maximum rate of depolarization in rabbit atrial and ventricular muscle?
Population
Rabbit atrial and ventricular muscle
Comparison
Lidocaine and diphenylhydantoin in solutions… vs Lidocaine and diphenylhydantoin in solutions…
Design
Preclinical
Authors
Loading...
Hypokalemia may blunt effects at therapeutic concentrations; leaves open translation of rabbit findings to clinical antiarrhythmic use.
Does altering potassium concentration affect the action of lidocaine and diphenylhydantoin on the maximum rate of depolarization in rabbit atrial and ventricular muscle?
The reduction of the maximum rate of depolarization by lidocaine and diphenylhydantoin is dependent on extracellular potassium concentration, suggesting their mechanism of action is similar to other antiarrhythmic drugs.
Singh et al. (1971) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: