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June 19, 2018IJC Heart & VasculatureOpen Access

Prognostic implications of high-sensitivity cardiac troponin T assay in a real-world population with non-ST-elevation acute coronary syndrome

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Why the study?

Does high-sensitivity cardiac troponin T (hsTnT) provide better prognostic stratification than contemporary cardiac troponin I (cTnI) for cardiovascular death or non-fatal MI in patients with NSTE-ACS?

Population

644 patients with CK-MB negative non-ST-segment elevation acute coronary syndromes (NSTE-ACS)

Comparison

High-sensitivity cardiac troponin T assay… vs Contemporary cardiac troponin I assay…

Design

Cohort

Follow-up

180 days

Authors

MMMarco MagnoniGGGuglielmo GalloneFCFerruccio Ceriotti

Discussion

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Overview

hsTnT did not improve risk stratification over cTnI in NSTE-ACS; leaves open its incremental prognostic value in routine practice.

Structured PICO

Does high-sensitivity cardiac troponin T (hsTnT) provide better prognostic stratification than contemporary cardiac troponin I (cTnI) for cardiovascular death or non-fatal MI in patients with NSTE-ACS?

P
Population
644 patients with CK-MB negative non-ST-segment elevation acute coronary syndromes (NSTE-ACS)
I
Intervention
High-sensitivity cardiac troponin T (hsTnT) assay stratification (≥99th percentile)
C
Comparator
Contemporary cardiac troponin I (cTnI) assay stratification
O
Outcome
Composite of cardiovascular death (CVD) or non-fatal myocardial infarction (MI) at 180 dayscomposite

In patients with NSTE-ACS, hsTnT provides good prognostic stratification for hard clinical endpoints but does not significantly improve prognostic ability over contemporary cTnI assays.

Cite This Study

Magnoni et al. (2018) studied this question.

synapsesocial.com/papers/6a762fd41c684509e2008aa3https://doi.org/10.1016/j.ijcha.2018.06.004
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