Mid-Regional Pro-Adrenomedullin Is Associated With Pulse Pressure, Left Ventricular Mass, and Albuminuria in African Americans With Hypertension
Why the study?
Is plasma MR-proADM associated with pulse pressure, left ventricular mass, and albuminuria in African-American adults with hypertension?
Population
1,034 African-American adults with hypertension, mean age 65 +/- 9 years, 72% women.
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
MR-proADM may mark target organ damage in hypertensive African-Americans; hypothesis-generating and should not yet change practice.
Structured PICO
Is plasma MR-proADM associated with pulse pressure, left ventricular mass, and albuminuria in African-American adults with hypertension?
P
Population
1,034 African-American adults with hypertension, mean age 65 +/- 9 years, 72% women.
I
Intervention
Plasma mid-regional pro-adrenomedullin (MR-proADM) measurement
O
Outcome
Association with pulse pressure, left ventricular mass indexed by height to the power 2.7 (LVMi), and urine albumin:creatinine ratio (UACR)surrogate
In African-American adults with hypertension, elevated plasma MR-proADM is independently associated with markers of target organ damage including increased pulse pressure, left ventricular mass, and albuminuria.
Cite This Study
Al-Omari et al. (2009) studied this question.