September 27, 2006Clinical Orthopaedics and Related Research
Thromboembolic Disease after Total Hip Arthroplasty
Why the study?
Do genetic predispositions increase the risk of venous thromboembolism in patients undergoing total hip arthroplasty?
Population
Patients undergoing total hip arthroplasty
Comparison
Genetic predispositions vs Matched controls
Design
Case-control
Authors
Discussion
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Member takes
Implication
May support genetic screening to stratify post-THA VTE risk; hypothesis-generating and requires prospective validation before practice change.
Structured PICO
Do genetic predispositions increase the risk of venous thromboembolism in patients undergoing total hip arthroplasty?
P
Population
Patients undergoing total hip arthroplasty
I
Intervention
Genetic predispositions (deficiency of antithrombin III < 75%, protein C < 70%, and prothrombin gene mutation)
C
Comparator
Matched controls
O
Outcome
Venous thromboembolismhard clinical
Preoperative genetic screening for antithrombin III, protein C, and prothrombin gene mutations can help stratify VTE risk in patients undergoing total hip arthroplasty to guide appropriate prophylaxis.
Cite This Study
Beksaç et al. (2006) studied this question.