December 27, 2017Heart RhythmOpen Access

Structural and functional remodeling of the atrioventricular node with aging in rats: The role of hyperpolarization-activated cyclic nucleotide–gated and ryanodine 2 channels

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Population

Male Wistar Hannover rats aged 3 months (n = 24) and 2 years (n = 15)

Comparison

Aging and pharmacological blockade with Cesium… vs Young rats and baseline without pharmacological…

Design

Preclinical

Authors

YSYawer SaeedAga Khan University Hospital ITIan P. TempleManchester University NHS Foundation Trust ZBZoltan BorbasUniversity of Liverpool

Discussion

Member takes

Implication

Aging-induced AVJ remodeling in rats may underlie AVN dysfunction; leaves open translation to human aging and clinical relevance.

Structured PICO

Population

Male Wistar Hannover rats aged 3 months (n = 24) and 2 years (n = 15)

Intervention

Aging (2 years old) and pharmacological blockade with Cesium (2 mM) or ryanodine (2 μM)

Comparator

Young rats (3 months old) and baseline without pharmacological blockade

Outcome

Electrophysiological parameters including Atrio-His (AH) interval, Wenkebach cycle length (WBCL), and AVN effective refractory period (AVNERP), as well as protein expression and morphological characteristicssurrogate

Aging in rats leads to structural and functional remodeling of the atrioventricular junction, with HCN and RyR2 channels playing an important role in age-related AVN dysfunction.

Cite This Study

Saeed et al. (2017) studied this question.

synapsesocial.com/papers/6a763968031c7cb28e008f6a https://doi.org/10.1016/j.hrthm.2017.12.027

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Structural and functional remodeling of the atrioventricular node with aging in rats: The role of hyperpolarization-activated cyclic nucleotide–gated and ryanodine 2 channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Structural and functional remodeling of the atrioventricular node with aging in rats: The role of hyperpolarization-activated cyclic nucleotide–gated and ryanodine 2 channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider