Why the study?
How do venous return conductance and mean circulatory filling pressure differ between Fontan and biventricular circulations in a pig model?
Population
Pentobarbital sodium-anesthetized pigs (n=16 total; 8 biventricular, 8 Fontan)
Comparison
Fontan circulation model vs Biventricular circulation model
Design
Preclinical
Authors
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Highlights altered venous dynamics in Fontan pig models; hypothesis-generating and leaves open human translation.
How do venous return conductance and mean circulatory filling pressure differ between Fontan and biventricular circulations in a pig model?
In a pig model of Fontan circulation, pulmonary vascular resistances induce a proportional decrease in venous return conductance, while volume loading increases mean circulatory filling pressure to maintain systemic blood flow.
Macé et al. (2000) studied this question.
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