What question did this study set out to answer?

To evaluate physiologic responses to incremental plasma concentrations of intravenous theophylline in order to establish a safe and effective dosage regimen.

September 20, 1973New England Journal of Medicine

Rational Intravenous Doses of Theophylline

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Authors

PMPaul A. MitenkoUniversity of Manitoba RORichard I. OgilvieGeneral / Preventive / Lipids

Discussion

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Implication

Clinical trial demonstrates log-linear lung function gains from intravenous theophylline in hospitalized asthmatics, suggesting an optimal loading and maintenance dosing regimen.

Key Points

To evaluate physiologic responses to incremental plasma concentrations of intravenous theophylline in order to establish a safe and effective dosage regimen.
Administered intravenous theophylline to hospitalized asthmatic subjects (N=9) to achieve incremental plasma concentration plateaus.
Measured changes in pulmonary function, including vital capacity and forced expiratory volume in one second (FEV1), across the plasma concentration range of 5 to 20 mg per liter.
Pulmonary function continuously improved across plasma theophylline concentrations of 5 to 20 mg per liter, varying directly with the logarithm of the plasma concentration.
An intravenous aminophylline loading dose of 5.6 mg per kilogram followed by a maintenance infusion of 0.9 mg per kilogram per hour produces a plasma concentration of approximately 10 mg per liter in 95% of patients.
The recommended dosing regimen produces recovery from approximately 30 to 40% of reversible pulmonary airway obstruction.

Cite This Study

Mitenko et al. (1973) studied this question.

synapsesocial.com/papers/6a763de059770ea2c0bcb3bb https://doi.org/10.1056/nejm197309202891202

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September 20, 1973New England Journal of Medicine

Rational Intravenous Doses of Theophylline

View Full Paper

Ask AI

Bookmark

Authors

PMPaul A. MitenkoUniversity of Manitoba RORichard I. OgilvieGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Clinical trial demonstrates log-linear lung function gains from intravenous theophylline in hospitalized asthmatics, suggesting an optimal loading and maintenance dosing regimen.

Key Points

To evaluate physiologic responses to incremental plasma concentrations of intravenous theophylline in order to establish a safe and effective dosage regimen.
Administered intravenous theophylline to hospitalized asthmatic subjects (N=9) to achieve incremental plasma concentration plateaus.
Measured changes in pulmonary function, including vital capacity and forced expiratory volume in one second (FEV1), across the plasma concentration range of 5 to 20 mg per liter.
Pulmonary function continuously improved across plasma theophylline concentrations of 5 to 20 mg per liter, varying directly with the logarithm of the plasma concentration.
An intravenous aminophylline loading dose of 5.6 mg per kilogram followed by a maintenance infusion of 0.9 mg per kilogram per hour produces a plasma concentration of approximately 10 mg per liter in 95% of patients.
The recommended dosing regimen produces recovery from approximately 30 to 40% of reversible pulmonary airway obstruction.

Cite This Study

Mitenko et al. (1973) studied this question.

synapsesocial.com/papers/6a763de059770ea2c0bcb3bb https://doi.org/10.1056/nejm197309202891202

Also Consider

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