Why the study?
Does acute cardiogenic pulmonary edema alter the pharmacokinetics of intravenous theophylline compared to normal subjects?
Population
9 patients with acute cardiogenic pulmonary edema and 19 normal subjects (total n=28).
Comparison
Theophylline administered intravenously. vs 19 normal subjects.
Design
Cohort
Follow-up
24 hr
Authors
Loading...
May warrant theophylline dosing caution in pulmonary edema; leaves open need for prospective validation.
Does acute cardiogenic pulmonary edema alter the pharmacokinetics of intravenous theophylline compared to normal subjects?
Acute cardiogenic pulmonary edema significantly prolongs theophylline half-life and decreases clearance, necessitating caution and avoiding repeated doses or constant infusions due to unpredictable toxicity.
Piafsky et al. (1977) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: