Why the study?
Does the time course of theophylline uptake correlate with its positive inotropic effect in guinea-pig isolated hearts?
Population
Guinea-pig isolated, electrically driven hearts perfused by the Langendorff method
Comparison
Theophylline and [(3)H]-theophylline perfusion vs Baseline conditions or caffeine pretreatment
Design
Preclinical
Follow-up
10 minutes (perfusion time)
Authors
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Supports sarcolemmal action in isolated hearts; leaves open relevance to human myocardium or practice.
Does the time course of theophylline uptake correlate with its positive inotropic effect in guinea-pig isolated hearts?
The positive inotropic effect of theophylline develops faster than its cellular uptake, suggesting its principal action is on the sarcolemma to increase calcium influx rather than solely intracellular.
Bellemann et al. (1974) studied this question.