Why the study?
Do theophylline and iminazole produce positive inotropic responses via increased calcium influx in isolated frog hearts?
Population
Isolated frog heart / isolated ventricles
Comparison
Theophylline and iminazole vs Control period / controls
Design
Preclinical
Follow-up
up to 60 minutes exposure
Authors
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Hypothesis-generating for calcium influx mediation of theophylline/iminazole inotropy in isolated frog hearts; mammalian studies required before clinical consideration.
Do theophylline and iminazole produce positive inotropic responses via increased calcium influx in isolated frog hearts?
The positive inotropic effects of theophylline and iminazole in frog hearts are likely due to increased calcium influx rather than phosphodiesterase inhibition.
Massingham et al. (1972) studied this question.
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