Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 1, 1990British Journal of PharmacologyOpen Access

Time‐dependent effects of theophylline on myocardial reactive hyperaemias in the anaesthetized dog

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does theophylline affect myocardial reactive hyperaemias in response to coronary occlusion and adenosine in anaesthetized dogs?

Population

Anaesthetized dogs

Comparison

Theophylline (5 mg kg-1 i.v. loading dose) vs Control (baseline before drug delivery)

Design

Preclinical

Follow-up

2 hours

Authors

JGJeffrey M. GiddayLouisiana State UniversityJEJohn W. EstherJohns Hopkins UniversitySEStephen ElyNova Southeastern University

Discussion

Loading...

Member takes

Implication

Theophylline shows time-dependent differential effects on canine coronary hyperaemia; leaves open translation to human vasomotor responses or adenosine testing.

Structured PICO

Does theophylline affect myocardial reactive hyperaemias in response to coronary occlusion and adenosine in anaesthetized dogs?

P
Population
Anaesthetized dogs
I
Intervention
Theophylline (5 mg kg-1 i.v. loading dose)
C
Comparator
Control (baseline before drug delivery)
O
Outcome
Hyperaemic responses to short-term (15 and 30 s) interruptions in coronary blood flow and intracoronary adenosine over a 2 h periodsurrogate

A single therapeutic dose of theophylline produces distinct time-dependent pharmacological effects on coronary vasodilation in response to ischemia and exogenous adenosine in dogs.

Cite This Study

Gidday et al. (1990) studied this question.

synapsesocial.com/papers/6a8349e8fd326746d0f2b16ehttps://doi.org/10.1111/j.1476-5381.1990.tb12058.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of aminophylline on coronary reactive and functional hyperaemic response in conscious dogs1984 · 10 citations
  2. 2Reactive hyperaemia in the dog heart: inter-relations between adenosine, ATP, and aminophylline and the effect of indomethacin1977 · 63 citations
  3. 3Intracoronary adenosine enhances myocardial reactive hyperemia after brief coronary occlusion1985 · 7 citations
  4. 4RELATIONSHIP BETWEEN THEOPHYLLINE UPTAKE AND INOTROPIC EFFECT IN THE GUINEA‐PIG HEART1974 · 14 citations
  5. 5Kinetics of pharmacologic effects in man: The anticoagulant action of warfarin1969 · 231 citations