Pharmacodynamic Interactions Between Infused Adenosine and Oral Theophylline

5 healthy human subjects

625 mg theophylline orally followed 4 h later by a 40 min infusion of adenosine (40 micrograms kg-1 min-1 for 5 min, 60 micrograms kg-1 min-1 for 5 min and 80 micrograms kg-1 min-1 for 30 min)

625 mg theophylline orally followed by 0.9% sodium chloride infusion, OR placebo theophylline tablets followed by adenosine infusion

Changes in diastolic blood pressure, pulse rate, respiratory rate, and metabolic parameters (plasma potassium and magnesium)surrogate