March 1, 1991American Journal of Hypertension

Theophilline Is an Antagonist of Adenosine in Human Forearm Arterioles

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Why the study?

Does theophylline antagonize adenosine-mediated vasodilation in hypertensive patients?

Structured PICO

Does theophylline antagonize adenosine-mediated vasodilation in hypertensive patients?

Population

10 hypertensive patients (n=5 for theophylline protocol, n=5 for papaverine protocol)

Intervention

Theophylline infused into the brachial artery (1000 micrograms/min for 20 min) followed by cumulative adenosine infusion (5, 15, and 50 micrograms/min for 3 min each)

Comparator

Papaverine infused into the brachial artery (100 and 300 micrograms/min for 20 min) followed by cumulative adenosine infusion

Outcome

Adenosine-mediated vasodilation measured by forearm blood flow via venous plethysmographysurrogate

Theophylline acts as a specific antagonist of adenosine in humans, suggesting this mechanism may be relevant for its pharmacological action rather than phosphodiesterase inhibition.

Discussion

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Implication

May support theophylline as adenosine antagonist in hypertension; hypothesis-generating for mechanism versus PDE inhibition.

Cite This Study

Taddei et al. (1991) studied this question.

synapsesocial.com/papers/6a890f98789d3eba981a2ab8 https://doi.org/10.1093/ajh/4.3.256

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Theophilline Is an Antagonist of Adenosine in Human Forearm Arterioles

Structured PICO

Discussion

Implication

Cite This Study

Theophilline Is an Antagonist of Adenosine in Human Forearm Arterioles

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider