December 1, 1990Circulation
Sympathetic nervous system-dependent vasoconstriction in humans. Evidence for mechanistic role of endogenous purine compounds.
Why the study?
Does local theophylline infusion increase sympathetic vasoconstriction induced by lower-body negative pressure in humans?
Population
Humans
Design
Other
Authors
Discussion
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Member takes
Implication
Should not alter clinical vasoconstriction management; extends mechanistic evidence for purinergic regulation beyond norepinephrine.
Structured PICO
Does local theophylline infusion increase sympathetic vasoconstriction induced by lower-body negative pressure in humans?
P
Population
Humans
I
Intervention
Local theophylline infused into the brachial artery at 100 micrograms/100 cc/min during lower-body negative pressure, with and without phenoxybenzamine (60 micrograms/100 cc/min)
O
Outcome
Forearm blood flow changes measured by strain-gauge venous plethysmography to assess arteriolar sympathetic vasoconstrictionsurrogate
The study demonstrates that purinergic receptors and neurotransmitters play a mechanistic role in endogenous sympathetic vasoconstriction in humans, independent of norepinephrine.
Cite This Study
Taddei et al. (1990) studied this question.