Why the study?
Does adenosine receptor inhibition with theophylline attenuate the skin blood flow response to local heating in humans?
Population
6 human subjects
Comparison
4 mM theophylline (a competitive, non-selective… vs Lactated Ringer solution administered via…
Design
Other, Sites were randomly assigned
Authors
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Adenosine contributes to cutaneous thermal hyperaemia; extends mechanistic understanding of NO-dependent vasodilation but leaves open clinical relevance.
Does adenosine receptor inhibition with theophylline attenuate the skin blood flow response to local heating in humans?
Adenosine receptor activation directly contributes to cutaneous thermal hyperaemia in humans, explaining a portion of the nitric oxide-dependent vasodilatory response.
Fieger et al. (2010) studied this question.
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