Why the study?
Does inhibition of TRPV-1 channels attenuate the skin blood flow response to local heating in humans?
Population
10 human subjects
Comparison
Microdialysis of 20 mM capsazepine, 10 mM… vs Vehicle control
Design
Other, Microdialysis fibres were randomly assigned one of four treatments
Follow-up
20-30 minutes
Authors
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No immediate clinical application; extends mechanistic understanding of cutaneous thermoregulation while leaving translation open.
Does inhibition of TRPV-1 channels attenuate the skin blood flow response to local heating in humans?
TRPV-1 channels contribute substantially to the initial peak and modestly to the plateau phases of thermal hyperaemia in human skin.
Wong et al. (2010) studied this question.
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